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UNITED STATES .P'ATENT oFFIcE.

OLIVER KAMM, OF URIBAINA, AND ERNEST H. VOLLWEILER, OF CHICAGO, ILLINOIS,

ASSIGNORS TO THE ABBOTT LABORATORIES, OF CHICAGO, ILLINOIS, A CORPORA- TION OF ILLINOIS.

DI (NORMAL) BUTYL BABBITURIC ACID.

No Drawing.

and which exhibits pronounced sedative properties and yet possesses a very low toxicity.- It was synthesized as is illustrated by the following example:

Illustration 40 grams of sodium are dissolved in 1 liter of absolute alcohol and 157 grams of dinormal butyl malonic ester (prepared by the action of n-butyl bromid upon malonic ester Specification of Letters Patent. 'i ateiited Feb. 24:, 1920. Application filed January 23, 1919. Serial in. 272,625.

in the' presenceoi' two moles of sodium ethylate) and 50 grams of urea added. The mixture is heated inan enameled autoclave during six hours at a temperature of 100 to 110 C. After the alcohol is distilled from the reaction mixture, water is added and the di-n-butyl barbituric acid precipitated by acidification with hydrochloric acid. The yield of crude product was 130 grams. It crystallizes from hot Water in the form of white needles which melt at 158 C.

We claim:

1. Di (normal) butyl barbituric acid.

2. As a new article of manufacture, the dinormal butyl derivative of barbituric acid, possessing the structure o oH om-om-cm Cl---NH which is a white crystalline solid melting at 158 (1., and which possesses marked hypnotic properties combined with a low toxicity. January 14, 1919.

OLIVER KAMM.

ERNEST H. VOLLWEILEB. 

